Schlagwort: Design
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Neprilysin
Directed Evolution (DE) in Enzyme Engineering example 2 engineered neprilysin with improved amyloid beta activity and specificity here at first only: „Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s Disease“ Carl I. Webster, Matthew Burrell, Lise-Lotte Olsson, Susan B. Fowler, Sarah Digby, Alan Sandercock, Arjan Snijder, Jan Tebbe, Ulrich Haupts, Joanna…
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Natriuretic Peptide engrafted Antibodies
Atrial natriuretic peptid (ANP) – UniProt P01160 Brain natriuretic peptide (BNP) – UniProt P16860 C-type natriuretic peptide (CNP) – UniProt P23582 „As drugs, both ANP and BNP, and derivatives of these peptides, seem promising as therapy in heart failure patients and in hypertension. Moreover, the cardiac peptide hormones may also possess organ-protective effects, where kidney…