Kategorie: Protein Engineering
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Enzyme Engineering
DE v.0 example 1 (2007) Successful Combinatorial Library and Confocal HTS Strategies for Extensive Optimization of a Human Protease J. Tebbe, C. Votsmeier, A. Scheidig, O. Hesse, P. Scholz, U. Beister, C. Götzberger-Schad, K. Baral, K. Odendahl, S. Haupt, N. Koch, N. Habrich, S. Frings, H. Plittersdorf, A. Rüter, M. Maass, K. Kirchner, K. Meyer,…
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Neprilysin
Directed Evolution (DE) in Enzyme Engineering example 2 engineered neprilysin with improved amyloid beta activity and specificity here at first only: „Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s Disease“ Carl I. Webster, Matthew Burrell, Lise-Lotte Olsson, Susan B. Fowler, Sarah Digby, Alan Sandercock, Arjan Snijder, Jan Tebbe, Ulrich Haupts, Joanna…
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HPPD variants
„4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is an enzyme engaged in photosynthetic activity and catalyzes the transformation of 4-hydroxyphenylpyruvic acid (HPPA) into homogentisic acid (HGA). HPPD inhibitors constitute a promising area of discovery and development of innovative herbicides with some advantages, including excellent crop selectivity, low application rates, and broad-spectrum weed control. HPPD inhibitors have been…
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# divers eins
The Nobel Prize in Chemistry 2020 was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna „for the development of a method for genome editing„ https://www.nobelprize.org/prizes/chemistry/2020/summary/ The Nobel Prize in Chemistry 2018 was divided, one half awarded to Frances H. Arnold „for the directed evolution of enzymes“, the other half jointly to George P. Smith…
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Natriuretic Peptide engrafted Antibodies
Atrial natriuretic peptid (ANP) – UniProt P01160 Brain natriuretic peptide (BNP) – UniProt P16860 C-type natriuretic peptide (CNP) – UniProt P23582 „As drugs, both ANP and BNP, and derivatives of these peptides, seem promising as therapy in heart failure patients and in hypertension. Moreover, the cardiac peptide hormones may also possess organ-protective effects, where kidney…